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Furthermore, the dual effects of BEZ235 on PI3K/Akt and mTOR signaling pathways inhibit the activation of fibroblasts and eliminate the defect of rapamycin in p-Akt feedback activation of Ser473 after treatment with TGF- [131]

While conventional medicine focuses primarily on symptom control through anti-inflammatory medications, injections, or surgery, these approaches rarely address the underlying biology of cartilage degeneration

10.1002/biof.1533 12 BissacottiB

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Ultimately, the choice depends on your needs, preferences, and circumstances