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doi:10.1128/JB.00261-13 [23] Comas-Baste O, Latorre-Moratalla ML, Bernacchia R, Veciana-Nogues MT, Vidal-Carou MC

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However, these downstream signaling pathways are widely distributed in cell types other than immune cells, which contributes to adverse events such as thrombosis

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These nonantimicrobial sulfonamides do not undergo metabolism to the N 4 -hydroxylated metabolite associated with SJS and will not bind to IgE at the N 1 position and, therefore, are unlikely to cause cross-reactivity, even in patients who have experienced type 1 hypersensitivity or serious non-type-1 hypersensitivity reactions to sulfonamide antimicrobial agents