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In addition, the applicant and commenter noted that several prior CMS transmittals (#R10997CP, #R11004CP, and #R11801CP) have stated that C1831 is to only be used in lumbar fusion procedures

These typically improve gradually as drug levels decline, though some patients report a temporary worsening of nausea during the first week after discontinuation before improvement occurs

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Although GLP-1 medicines are generally well tolerated, there have been reports of rare but serious cases of acute pancreatitis, a painful and potentially severe inflammation of the pancreas