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The risk is not zero, but nuanced and should be discussed

It works by mimicking two naturally occurring hormones, GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which play essential roles in regulating appetite and metabolizing glucose

Visual changes become dramatic enough that friends and family comment unprompted

GLP-1 receptor agonists, such as semaglutide bind to GLP-1 receptors on beta cells in the pancreas and stimulate insulin release when food is ingested

Combination therapy also produced favorable changes in multiple cardiometabolic risk factors and patient-reported quality of life while maintaining an acceptable safety profile consistent with previous experience for both medications