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The populations studied ranged in size from 3297 (SUSTAIN-6) to 14,752 (EXSCEL), were of similar age (mean age was 64.0 1.97 years), 37,117 were male (62.8%), and the median duration of follow-up ranged from 1.3 to 5.4 years

Prescriptions filled within 10 days had the greatest percent decrease (compared to prescriptions filled within 5 and 30 days)

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The argument for coverage is that retatrutide is durable enough to push patients out of obesity entirely in two thirds of cases which over a decade is cheaper than treating the cardiovascular, metabolic, and orthopedic complications of long-term obesity