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8 Remaining Questions and Knowledge Gaps There is strong evidence that synovitis drives worse outcomes in osteoarthritis, contributing to more severe and persistent pain, heightened pain sensitization, faster structural deterioration, and an increased need for joint replacement

As for chemotherapy, trials have shown that when coupled with Cisplatin, there was a significant reduction in nephrotoxicity in patients with ovarian cancer, as well as a greater tumor response

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doi: 10.1056/NEJM200101043440101