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DOQ and AM can react and conjugate with many biomolecules, including protein residues cysteine and tyrosine with sulfhydryl and hydroxyl groups, whereas polymerization of AM will form neuromelanin (NM), an insoluble granular pigment in SN [5, 25, 26]

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The overall effects of vitamin E supplementation both in human and rodents studies are shown schematically in Figure 6

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Because compounded drugs do not have the guardrails, nor have they been tested in large populations, there are risks associated with them, and they therefore should never be produced on a mass marketing basis except in very limited situations where the FDA has declared a shortage of drugs in high demand