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250,251 The inability to consistently access sufficient and nutritious food affects an individuals ability to adhere to an obesity treatment plan, particularly given the importance of dietary modifications to optimize the benefits of GLP-1 use, reduce nutrient shortfalls, and manage side effects

Wilding JPH, Batterham RL, Calanna S et al (2021) Once-weekly semaglutide in adults with overweight or obesity

During fasting, hypoglycemia, or physiologic stress, glucagon increases hepatic glucose production through glycogenolysis and gluconeogenesis

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Gould notes, they havent been fully demonstrated in human tissue or large-scale trials. Whats more, it can be hard to tease out the influence of GLP-1s from that of age and hormones, which can similarly undermine our tissues