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Even if it is still unclear whether OS is a primary or a secondary cause of neurodegeneration in ALS, overwhelming evidence indicates the pathological role of OS, and alterations in KEAP1 and NRF2 expression and in KEAP1-NRF2 activity may explain the progressive MN degeneration and death associated with ALS [170]

Wang ZH, Fu BQ, Lin YW, Wei XB, Geng H, Guo WX, et al

Methionine is an essential amino acid, which means it cannot be synthesized within the human body and must be consumed from the diet, whereas cysteine is a conditionally essential amino acid, meaning there may be some situations when the bodys need for the amino acid outweighs its ability to create it

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