It has multiple actions including: potentiation of glucose-mediated insulin secretion mechanisms identified: increased -cell proliferation, resulting in an increase -cell mass (Fusco et al, 2017) stimulation of insulin biosynthesis at the translational level, helping to maintain -cell insulin stores and secretory capacity (Baggio & Drucker, 2007) because the GLP-1 effect is glucose-dependent (there is more insulin release when glucose levels are elevated, but less effect when glucose levels are normal), GLP-1 agonists have a lower risk for producing hypoglycemia compared to sulfonylureas (that chronically stimulate insulin release, independent of glucose concentration) suppression of postprandial glucagon release Evidence indicates that stimulation of pancreatic cells by GLP-1 increases their glucose sensitivity, resulting in less glucagon release at any glucose level (Baggio & Drucker, 2007)
This is a Feature, Not a Bug The return of food noise can feel dishearteningbut its not a backslide
Outcomes Outcomes of interest were related to the safety and efficacy of GLP-1 RMs for use in patients who experience dumping syndrome following MBS
Available online at: 37 GarveyWRyanDLookMGaddeKAllisonDPetersonCet al
Additionally, meta-analyses indicate that the association between obesity and anxiety disorders may be more pronounced in women than in men (89, 104-106)
