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We ascribed it to initial formation of a 1:1 complex that gradually got displaced by a 1:2 complex (peptide:Cu)

Besides ATF4, another transcription factor that regulates xCT expression is the nuclear factor erythroid 2-related factor 2 (NRF2) via the antioxidant response element (ARE) present in the promoter region of xCT gene (40, 41)

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2011;25:9558 Marklund SL, Holme E, Hellner L