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Plasma and erythrocyte ChE activities were decreased throughout the study in the two highest dose groups compared with controls, but brain ChE activity was decreased in the highest dose group only

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Also, additional environmental factors such as pollutants may also affect its level

Discussion This study demonstrated that metformin exerts its glucose-lowering effects primarily by modulating intestinal glucose handling through increased glucose uptake and excretion in the distal intestine, specifically the ileum and colon

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