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GLP-1 class dynamics illustrate a fundamental pharmacoeconomic truth: first-in-class validates the mechanism, but the real market expansion happens when subsequent entrants differentiate on dosing interval, tolerability, and delivery, creating multiple blockbusters from a single validated biological pathway

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How Tirzepatide (Zepbound) & Semaglutide (Wegovy) Work Tirzepatide and semaglutide work by restoring the GLP-1 and GIP peptide hormones your body becomes deficient in over time the hormones responsible for regulating: appetite and cravings fullness and satisfaction insulin response and blood sugar how much fat you store versus burn When these peptide hormones are low, weight loss becomes biologically blocked no matter how disciplined you are

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