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Examination and Diagnostic Testing Accurate diagnosis is the cornerstone of effective treatment

Pituitary GH mRNA and hypothalamic GH-releasing hormone mRNA, and GH secretagogue receptor (GHSR) mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment group

Lactiplantibacillus plantarum C29 (often delivered as a fermented soybean preparation called DW2009) Evidence Randomized controlled trials in older adults with mild cognitive impairment showed: improved attention and memory scores increased brain-derived neurotrophic factor (BDNF) Proposed mechanism reduces gut inflammation increases BDNF (supports neuron survival and plasticity) improves gut barrier and reduces endotoxin signaling to the brain Strength of evidence: One of the strongest probiotic strains studied specifically for cognition in older adults 2

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doi: 10.1186/s13046-023-02815-w 72 RuanJOuyangMZhangWLuoYZhouD