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By understanding the inner workings of our immune systemspecifically the transition of macrophages from destructive M1 troops into constructive M2 rebuilderswe can actively dictate the speed and aesthetic quality of our recovery

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Mechanistically, the use of TMP-195 interferes with the interaction between HDAC9 and STAT1, reduces the deacetylation level of STAT1 in HK-2 cells, and prevents its phosphorylation and reactivation, thereby inhibiting G2/M phase arrest of TECs and alleviating renal tubulointerstitial fibrosis (Zhang et al., 2023c)