According to recent studies, taking hydroquinone orally is toxic and may lead to exogenous ochronosis, resulting in pigmented spots on the skin
The loading doses are generally smaller, fractionated injections designed to steadily increase receptor exposure without overwhelming the system in a single large bolus
However, the differences in the binding motif, and the flexibility displayed by PUF-11, suggest that the PUF proteins may repress distinct pools of mRNAs in order to ensure proper balance, thereby displaying pathway redundancy in order achieve the same overall outcome (i.e., inhibiting meiosis and/or sex determination) (Koh et al., 2009)
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They are rare, but can occur during or even after treatment