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Iran J Kidney Dis 2008

Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

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Biochem Soc Trans 33:13751377 Huang K, Czymmek KJ, Caplan J, Sweigard JA, Donofrio NM (2011) HYR1-mediated detoxification of reactive oxygen species is required for full virulence in the rice blast fungus

Improved cellular function The removal of dysfunctional senescent cells allows healthy cells to function better, thereby improving overall tissue maintenance and repair (4)