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"Not FDA-approved" just means the FDA hasn't reviewed or signed off on its safety, efficacy, dosing, or manufacturing for people
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(2019) 8:e011037
Conclusion GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology and the leading pacemaker site through a calcium signalling response characterized by PKA-dependent phosphorylation of Ca 2+ cycling proteins involved in pacemaking
Mathew VanZant Jordan Stevenson Marcus Kindervater Barbora Balnov Abby-Jo Payne Paul Bichler Laila Kott Jean-Franois Vincent-Rocan Link: To view or add a comment, sign in Discover how continuous flow hydrogenation is transforming epilepsy drug synthesis
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