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Organization, control and function of extrasynaptic NMDA receptors

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective

This helps keep down inflammation, which most health professionals agree is a major cause of the plaque formation that contributes to atherosclerosis

Based on their biogenesis and size, EVs are classified into three main subtypes: Exos (30150 nm in diameter), microvesicles (1501000 nm in diameter), and apoptotic bodies (502000 nm in diameter) (recently reviewed [54,55,56]

Revealing chromatin-specific functions of histone deacylases