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Offering clinical promise, in vitro data using primary enteroendocrine cells and an intestinal cell line indicated that pharmacologic TGR5 agonists are more potent GLP-1 secretagogues and are better at enhancing L-cell responses to calcium and glucose-induced GLP-1 secretion compared to naturally occurring bile acids (180)

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Injections almost certainly raise blood levels more efficiently, but high-quality trials proving the injectable form produces better real-world fat loss are limited

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Whilst Wegovy is licensed in the UK as a GLP-1 receptor agonist for chronic weight management, Qsymia is not authorised for use in the UK or European Union