Does oral semaglutide reach the brain
2018 [cited 2022 Jan 12];14:938
Semaglutide is a GLP-1 receptor agonist that works by: Reducing appetite Increasing fullness Slowing gastric emptying Improving insulin sensitivity Brand-name versions include: Ozempic (commonly used off-label for weight loss) Wegovy (FDA-approved specifically for chronic weight management) Semaglutide has one of the largest bodies of clinical evidence in obesity medicine

Some of the most common side effects are: Nausea Constipation Headache Vomiting Dizziness Insomnia Dry mouth Diarrhea Anxiety Hot flushes Fatigue Tremors Upper abdominal pain Viral gastroenteritis Influenza (flu) Tinnitus (ringing in the ears) Urinary tract infection Excessive sweating Irritability Increased blood pressure Changes in taste and smell Rashes Muscle strains Palpitations (heart racing) Additional but less common side effects may include: Fast heart rate, heart attack, dizziness, motion sickness, lower abdominal pain, gas, lip swelling, rectal bleeding, hernia, inflamed gallbladder, pneumonia, staph infection, kidney infection, increased blood creatinine, increased hepatic enzymes, decreased hematocrit, feeling jittery, feeling abnormal, feeling weak or a loss of energy, thirst, feeling hot, disturbance in attention, feeling sleepy, tremors, balance disorder, impaired memory, amnesia, abnormal dreams, nervousness, feeling spacey, tension, agitation, mood swings, abnormal and frequent urination, dehydration, bulging or herniated discs, jaw pain, feeling faint, hair loss, erectile dysfunction, vaginal dryness, and irregular menstrual cycles (periods)

Are There Any Side Effects to Wegovy