Nrf2 orchestrates redox homeostasis by inducing genes encoding GPX4, FTH1, NQO1, and HO-1, thereby stabilizing GSH pools, suppressing lipid peroxidation, and modulating iron and mitochondrial metabolism (144, 145)
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Alcohol depletes glutathione: Chronic alcohol consumption severely reduces hepatic glutathione through increased oxidative stress during ethanol metabolism [6][35]
