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Lipid peroxidation by-products, including primary lipid hydroperoxides (LOOH), malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), continuously accumulate during ferroptosis in cancer cells and facilitate cell membrane rupture and ferroptosis occurrence ( 3.3 Antioxidant defense system Ferroptosis is a complex process interwoven with the imbalance between iron metabolism, lipid peroxidation and antioxidant defense in cells

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4.3% with placebo), hypersensitivity, including severe reactions (3.2% vs

J Biol Chem 192:1727 Creissen G, Reynolds H, Xue YB, Mullineaux P (1995) Simultaneous targeting of pea glutathione reductase and of a bacterial fusion protein to chloroplasts and mitochondria

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