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Mediation analysis demonstrated that 82.8% of steatosis improvement, 71.6% of ballooning reduction, and 69.3% of MASH resolution were attributed to weight loss, while only 25.1% of the fibrosis benefit was weight-related, indicating that other mechanisms other than weight loss may also play a role in the histological improvements associated with semaglutide

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The Mediterranean diet has demonstrated consistent benefits for cardiometabolic health in clinical studies

These numbers matter because GLP-1s slow down digestion and change gut motility, which is why side effects like nausea, constipation, diarrhea, bloating, and gas are so common