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Weeks 1-4 involve adjustment with possible increased shedding as the medication takes effect

Published Research NNMT Inhibition and Adiposity Neelakantan et al

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Before this meta-analysis, the IM route was generally the preferred route, but our results showed that no route is usually preferred, and SL and oral routes should be considered comparable alternative routes

This represents a significant gap between regulatory approval for safety (as a food substance) and clinical efficacy (which is absent or insufficient for weight loss)