Brioschi, S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, et al
So I built it
Similar considerations may limit the utility of the injectable agents, tirzepatide (dual GLP-1 and glucose-dependent insulinotropic polypeptide [GIP] agonist), and retatrutide (triple glucagon, GIP, and GLP-1 receptor agonist)
The potential loss of essential homoeostatic astrocyte functions includes (i) down-regulation of glutamate uptake that disturbs circuit function and increases excitotoxic potential 141,142,143
One study published in 2021 compared 1961 adults in a weight-loss program using either a once-weekly semaglutide subcutaneous injection with lifestyle changes or placebo with lifestyle changes for 68 weeks