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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [35]

This is when your body does most of its muscle repair and recovery work, and when important hormones like growth hormone are released

For example, GLP-1R agonism has been shown to reduce cocaine-seeking behaviors in mice, as measured by intravenous self-administration (IVSA) paradigms (Sorensen et al., 2015)

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