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SS rats exhibit significant changes in plasma amino acid levels and skeletal muscle amino acid metabolism compared with SS.13 BN rats or in response to a high-salt diet, especially glycine, serine, and threonine metabolism and alanine, aspartate, and glutamate metabolism 93,109

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For example, in one double-blinded randomized controlled trial on 46 patients with coronary artery disease, one group was given a single dose of 2 grams of vitamin C and longer-term treatment with 500 mg of vitamin C versus a placebo control

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