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Pharmaceuticals Memorable moments in 2023 The moments, numbers, and news that the C&EN team found noteworthy this year by Laura Howes Open-source drug discovery prepared for the next pandemic New antiviral drug leads were reported by an open-source drug discovery effort, the COVID Moonshot Consortium ( Science 2023, DOI: 10.1126/science.abo7201)

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Aging and skin cancer Aging is a tumor suppressor reaction, when the cancer stress stimulation, p53, and p16 tumor suppressor proteins control ways are established, so as to prevent stress cells in cell cycle progression and ultimately to the development of malignant tumor (154)

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