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GPX4 inhibition with RSL3 induces ferroptosis, lipid peroxidation and reactive oxygen species (ROS) in thyroid cancer cells in vitro We targeted the ferroptosis pathway in PTC cells in vitro using a pharmacologic inhibitor of GPX4, RSL3
(RT) CAS RN : 22465-48-1 Molecular Formula : C62H89CoN13O15PC2H4O2 Molecular Weight : 1406.41 Close Close Close Close Close Close Structural Formula Label Packing Document Application Overview / Applications Property Manufacturer Information Alias Same CAS list Related Information Document SDS EN Product Specification Sheet EN Package Insert Spectral Data Certificate of Analysis 1G 5G 100mg Calibration Certificate Analytical Charts Application Overview / Applications Property Manufacturer Information Alias Same CAS list For research use or further manufacturing use only
Causes: oversupplementation Clinical features In infants: increased risk of necrotizing enterocolitis (NEC) High-dose supplementation: alteration of vitamin K metabolism anticoagulatory effects of warfarin risk of bleeding Increased incidence of heart failure, subarachnoid hemorrhage, and increased mortality [10] Therapeutic uses Nonalcoholic steatohepatitis: consider vitamin E for antioxidant effect Characteristics Synonyms Vitamin K 1 (phytomenadione, phytonadione, or phylloquinone) Vitamin K 2 (menaquinone) Substance class: naphthoquinones Chemical structure: Vitamin K1 Vitamin K2 Inactive precursors (provitamins): none Active form: vitamin K hydroquinone Sources Leafy green vegetables (vitamin K 1 ) Eggs, dairy, and meat (vitamin K 2 ) Synthesized in small amounts by intestinal bacteria Transport: via lipoproteins
Michelle van der Schoot for language editing and reviewing
recent clinical trials have demonstrated that biotin works synergistically with chromium to lower fasting blood glucose and improve HbA1c, while also supporting the gut microbiome's ability to regulate insulin
