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Langston J.W., Ballard P., Tetrud J.W., Irwing I., Chronic parkinsonism in humans due to a product of meperidine- analog synthesis, Science 219 (1983) 979-980

It is smaller, which improves tissue penetration

Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

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