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Description

physiology 285, L671L679

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Caspase-3 activation represents point of no return in apoptosis

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It activates two receptors instead of one [3]

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Instead, therapeutic modulation of GSH must be tailored to disease context, reflecting the fundamental GSH paradox: whereas cancer therapy often seeks to deplete elevated GSH to induce oxidative stress and cell death, neurodegenerative and inflammatory diseases may require restoration of GSH homeostasis

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