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Most patients describe the sensation as pressure rather than sharp pain

this inflammation further depletes glutathione, which in turn prevents the liver from clearing the histamine, leading to even more mast cell reactivity

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BCL2L1 and BCL2 are anti-apoptotic proteins belonging to the BCL2 family that function by preventing the oligomerization of the BAX and BAK proteins and maintaining the integrity of mitochondrial membrane, thus inhibiting cell apoptosis at high expression 37

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