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Schisandrins elimination half-life (t 1/2 ) in females was 2-fold longer, while maximal plasma concentration (C max ) was 10-fold higher than in males ( 1/2 time of schisandrin in female rats was prolonged by two times, and the C max value was also increased by 20 times ( From a pharmacokinetic perspective, Schisandra lignans generally exhibit reasonable gastrointestinal absorption and favorable penetration into the liver-intestinal axis, supporting their potential for oral administration and application in hepatology

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