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Claus Ziegler Simonsen: nothing to disclose E-Posters - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy P2040 - ESOC25-817 EFFICACY AND SAFETY OF NERINETIDE IN ACUTE ISCHEMIC STROKE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF PRE-CLINICAL AND CLINICAL STUDIES Hala Azhari 1 1 Umm Al-Qura University, College of Medicine and Pharmacy, Mecca, Saudi Arabia Background and Aims: Ischemic stroke is a major cause of global disability and mortality, highlighting the need for effective neuroprotective agents