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B-vitamin supplementation may slightly reduce risk of stroke, but these benefits may not be seen in patients with chronic kidney disease

Quercetin exerts neuroprotective effects through the upregulation of p-Akt expression, downregulation of p-ASK1, p-JNK3, and cleaved caspase-3 expression, and inhibition of neuronal apoptosis (Pei et al., 2016)

This perspective strongly suggests the necessity for strategies that re-unlock the fibrotic microenvironment itself, fixed by oxidative stress beyond simple antioxidant or anti-inflammatory approaches (Shi et al

Mol Biol Rep (2022) 49(7):628593

Valcourt U, Alcaraz LB, Exposito JY, et al