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926 Hepatic hepcidin expression is significantly reduced, and iron homeostasis is altered in hepatic Hdac3 -specific knockout mice ( Hdac3 -LKO mice)

Pretreatment with Gem, but not nutlin-3, also delayed the onset of ferroptosis in p53 null H1299 cell lines (Fig S3A and B)

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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11