It is present in nearly every cell and is particularly concentrated in the liver
Free Radical Biol Med (1995) 19:22750
While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction ( Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol (Mugford et al., 2009)
monocytogenes has perhaps the most complex relationship with GSH that has been described, as it not only imports GSH as a cysteine source with a dedicated GSH transporter 19 , but it senses the host reducing environment and synthesizes its own GSH that post-translationally modifies and activates the master virulence transcription factor PrfA 16,17,18
Moreover, women who formerly used oral contraceptives were 54% more likely to have a pathology-confirmed adenomyosis diagnosis (POR = 1.54, 95% CI = 1.28-x-1.85) (Templeman et al., 2008)
