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Patients in the dose-escalation phase have increased risk of gastric emptying delay, and this phase often lasts four to eight weeks

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81 At the intracellular level, GLP1R engagement activates cAMP/PKA 86 and EpacPI3K/Akt cascades, 82 , 87 while inhibiting NFB 81 and MAPK pathways 88 , 89 molecular programs that enhance mitophagy, improve mitochondrial membrane potential, and promote mitochondrial quality control

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