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PMID: 33260933[PubMed Reference] Chang CH, Tsai WC, Lin MS, et al

Computational approaches in this domain included: Physiologically-based pharmacokinetic (PBPK) modeling Blood-brain barrier permeability prediction Metabolic stability simulation In silico toxicity assessment Drug-drug interaction prediction These computational predictions helped researchers prioritize compounds with optimal pharmacokinetic profiles before investing in expensive animal studies and clinical trials