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IGF-1 has a U-shaped relationship with health

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Similarly, chronic intermittent administration of GLP-1R agonists to diabetic rodents is associated with inhibition of food intake, improvement of glycemia, and reduction in hemoglobin A1c (HbA1c), demonstrating that repeated administration of GLP-1 is not associated with a diminished therapeutic response in vivo (Szayna et al., 2000

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Three studies comprising 41,984 exposed pregnancies and 136,485 comparator pregnancies found no statistically significant association with cardiac congenital malformations (OR 0.92