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Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-Dihydroxyphenyl)--valerolactone as the major metabolites

Rare kidney-related complications reported include acute kidney injury in patients with severe dehydration or pre-existing renal disease

The histone MS data are in Supplementary Table 3

Acknowledgements This research was supported by National Key R&D Program of China (2021YFF0702600), the National Natural Science Foundation of China (82222056 and 82111530099), Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510), the Natural Science Foundation of Guangdong (2022A1515012316), the Guangdong International Joint Research Program (2020A0505100027), and National Key Clinical Discipline

Maes M, Ringel K, Kubera M, et al