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The nicotinic cholinergic system also regulates the E/I balance and has been investigated as a potential therapeutic target

71,533,601,602,603,604 Morphological atrophy of astrocytes develops in a brain-region-linked fashion, starting first in the entorhinal and prefrontal cortices (which are, incidentally, the most vulnerable to AD) and then spreading to hippocampus

Inflammatory mediators induce neuroinflammation, synaptic dysfunction, hyperphosphorylated tau generation, A production, and neurodegeneration in the brain (Mohammadzadeh Honarvar et al., 2017)

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duration , and downstream biomarker readouts all within a Research Use Only framework (not for human consumption)