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The peptide increases VEGFR2 without increasing VEGF-A, the ligand that typically activates this receptor

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In our recent work ( The observed negative correlation between 5-HIAA and BDNF in our pediatric patients ( Table 3 ) leads us to speculate that 5-HIAA may negatively affect the maintenance and survival of neurons and synaptic plasticity regulated by BDNF ( Information on NEO and BIO levels in depressed children and adolescents is only sporadic and quite heterogeneous

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Absorbance was measured at 760 nm using a spectrophotometer (PerkinElmer Lambda 20, Waltham, MA, USA), with distilled water used as a blank