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Assess the timing Many patients notice that libido changes are most pronounced during dose escalation phases, when the medications effects on the nervous system are most acute

Fattah-alhosseini A, Chaharmahali R, Alizad S, Kaseem M, Dikici B

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

You should apply it once or twice a day