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Mean body-weight loss from each drugs pivotal Phase 3 trial (SCALE for liraglutide 3.0 mg

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Conclusion Outside of addiction, the psychiatric effects of these drugs appear limited

This vascular mechanism may help explain why GLP-1RAs consistently show reduced dementia incidence in large observational cohorts, even when effects on amyloid burden or short-term cognition are modest [13,14,15]

GLP-1 receptor agonists as a class share similar mechanisms and therefore comparable digestive effects, though individual medications show some distinctions