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The men, who had an average age of 46, were enrolled in the study and then entered a six-month pre-treatment phase, during which symptoms were monitored but no therapies were administered

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Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)

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