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The approach differs significantly between deficiency with and without neurological involvement

To administer the Naso B12 Nasal Spray, gently blow your nose before application, close one nostril, and spray the medication into the other while taking a deep sniff to ensure it reaches deep into the nasal passage

Without enough water, the B12 cant reach all the nooks and crannies of your system

This probably also includes the serotonin transporter SERT, which inhibits the effect of serotonin