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Research has linked elevated levels of sphingosine with reductions in depressive-like behavior and improvements in cognitive function [61]

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Additionally, a case report of a child with autistic disorder and cerebral folate deficiency showed the normalisation of low cerebral spinal fluid homocysteine following 2 weeks supplementation with 0.5 mg folinic acid/kg/day increasing to 1.0/kg/day for 3 months [54]