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Journal of Physiology, Paris, 97 (23), 221226

The enzyme encoded by the AADAT gene has two aminotransferase activities, one of which is utilized in the saccharopine pathway of lysine catabolism, the other is used in the transamination of kynurenine

Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery

Thanks to Irene Benito de Cuesta for her interest and engaging discussion, also to Keying Zhu for his interesting input

Malakouti M, Hoxie D, No DJ, Jacob SE (2022) Methotrexate